Kindling, Prenatal Exposure to Ethanol and Postnatal Development Selectively Alter Reponses of Hippocampal Pyramidal Cells to NMDA

摘要: Research that built upon the discovery by Collingridge and his colleagues (1983) induction of long-term potentiation (LTP) requires activation NMDA receptor has led to realization many higher brain phenomena depend on receptor. LTP is regarded as one key cellular events links experience memory learning. Thus several groups have sought obtained evidence must be activated for certain types associative learning occur (Morris et al., 1986; Lincoln 1988; Mondadori 1989). Activation appears a prerequisite also experience-dependent modifications neuronal response properties in developing visual cortex (Kleinschmidt 1987) stimulus train-induced bursting, homologue epileptogenesis (Anderson 1987). It can even influence morphological (Pearce 1987; Brewer Cotman, 1989) biochemical (Moran Patel, differentiation neurons. These effects are believed result from substantial entry Ca2+ through channel, which occurs if plasma membrane sufficiently depolarized at time (Ascher Nowak, Although these forms plasticity their receptor, there yet no any role this endurance or permanence change. In fact, Schaffer collteral-commissural synapse hippocampal area CAl been shown long-lasting increase quisqualate receptor-mediated component EPSP, with little change compo­nent (Kauer Muller Lynch, Davies