Competing events determining relapse-free survival in limited small-cell lung carcinoma. The French Cancer Centers' Lung Group.
作者： R Arriagada , A Kramar , T Le Chevalier , H De Cremoux
DOI: 10.1200/JCO.1992.10.3.447
关键词:
摘要: PURPOSEWe report results in terms of relapse-free survival (RFS), obtained patients with limited small-cell lung carcinoma (SCLC) treated by four consecutive alternating protocols, using a competing risk approach local recurrences, distant metastases, and death unrelated to cancer as events.PATIENTS AND METHODSTwo hundred two SCLC were included protocols radiotherapy chemotherapy (CT). The schedule consisted six cycles CT (doxorubicin, etoposide [VP16213], cyclophosphamide [CAVP16], plus methotrexate the first protocol; cisplatin replaced other three protocols) courses thoracic at total dose 45, 55, 65, 61 Gy respectively (accelerated hyperfractionation was used course fourth protocol). A 1-week rest followed each cycle radiotherapy. Seventy-six percent com...
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