Prophylactic cranial irradiation in limited-stage small-cell lung cancer: a retrospective analysis.

摘要: OBJECTIVE It is well established that prophylactic cranial irradiation (PCI) decreases significantly the incidence of brain metastases (BM) and increases overall survival in limited-stage small-cell lung cancer (LS-SCLC) patients with complete response to induction therapy. The aim this study was a review analysis PCI use among diagnosed LS-SCLC community hospital. METHOD A retrospective medical charts between January 1997 December 2002 at local hospital Fargo, North Dakota, done determine which these subsequently received PCI. Data on patient's age, gender, body mass index diagnosis, SCLC anatomical site, other comorbidies treatment SCLC, chemotherapeutic agents used diagnosis treatment, use, reason(s) for no PCI, BM status, sites, were abstracted. RESULTS total 32 identified. Twenty-three (71.9%) concurrent chemotherapy radiation Of remaining 9 (28.1%) patients, 6 (18.7%) did not receive any because poor performance 3 (9.4%) only coexisting comorbidity. Thirteen (40.6%) achieved but 4 (30.8%) had Among (69.2%) who appeared eligible 1 (11.2%) refused, (44.4%) comorbidities, notes indicating why they those (25%) patient developed 35 months later. CONCLUSION This found although few nevertheless, benefits could be significant. We concluded oncologists should more willing offer procedure.