Controlled clinical trial of prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission.
作者： Agnès Laplanche , Isabelle Monnet , Juan Antonio Santos-Miranda , Etienne Bardet , Cécile Le Péchoux
DOI: 10.1016/S0169-5002(98)00056-7
关键词:
摘要: We conducted a randomised clinical trial on 211 patients with small-cell lung cancer in complete remission (CR). The aim of this was to evaluate the effect prophylactic cranial irradiation (PCI) overall survival. Eligible were randomly assigned receive either PCI (100 patients) or no (111 patients). Each centre allowed use its own protocol as long total dose within range 24-30 Gy and delivered less than 3 weeks fractions less. mean follow-up is 5 years. survival curves do not differ significantly (P = 0.25) between two groups. 4-year rate (95% confidence interval) 22% [15-32%] group versus 16% [10-25%] control group. relative risk death compared 0.84 CI [0.62-1.13]). incidence brain metastasis lower group, but difference statistically significant 0.14). cumulative 44% [32-57%] 51% [38-63%] In conclusion, study, which had be closed prematurely, found terms metastases nor
elsevier.com
sci-hub.se 参考文章(39)
Wesley Mn, Whitacre My, Wiernik Ph, Van Echo Da, Aroney Rs, Aisner J, Slawson Rg, Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma. Cancer treatment reports. ,vol. 67, pp. 675- 682 ,(1983)
Steven T. Rosen, Robert W. Makuch, Allen S. Lichter, Daniel C. Ihde, Mary J. Matthews, John D. Minna, Eli Glatstein, Paul A. Bunn, Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small cell lung cancer The American Journal of Medicine. ,vol. 74, pp. 615- 624 ,(1983) , 10.1016/0002-9343(83)91019-7
H.H. Hansen, F.R. Hirsch, J. Rygard, M. Hansen, P. Dombernowsky, Prophylactic irradiation in bronchogenic small cell anaplastic carcinoma Cancer; (United States). ,(1980)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
M Lishner, R Feld, D G Payne, U Sagman, J P Sculier, J F Pringle, J L Yeoh, W K Evans, F A Shepherd, E Maki, Late neurological complications after prophylactic cranial irradiation in patients with small-cell lung cancer: the Toronto experience. Journal of Clinical Oncology. ,vol. 8, pp. 215- 221 ,(1990) , 10.1200/JCO.1990.8.2.215
Kenneth J. Rothman, Estimation of confidence limits for the cumulative probability of survival in life table analysis Journal of Chronic Diseases. ,vol. 31, pp. 557- 560 ,(1978) , 10.1016/0021-9681(78)90043-7
Michael Schemper, Terry L. Smith, A note on quantifying follow-up in studies of failure time Controlled Clinical Trials. ,vol. 17, pp. 343- 346 ,(1996) , 10.1016/0197-2456(96)00075-X
H. G. Seydel, R. Creech, M. Pagano, O. Salazar, P. Rubin, J. Concannon, P. Carbone, M. Mohuiddin, C. Perez, M. Matthews, Prophylactic versus no brain irradiation in regional small cell lung carcinoma. American Journal of Clinical Oncology. ,vol. 8, pp. 218- 223 ,(1985) , 10.1097/00000421-198506000-00005
L. Herbert Maurer, Marchant Tulloh, Raymond B. Weiss, Johannes Blom, Louis Leone, Oliver Glidewell, Thomas F. Pajak, A randomized combined modality trial in small cell carcinoma of the lung comparison of combination chemotherapy‐radiation therapy versus cyclophosphamide‐radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation Cancer. ,vol. 45, pp. 30- 39 ,(1980) , 10.1002/1097-0142(19800101)45:1<30::AID-CNCR2820450107>3.0.CO;2-6
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25