Prophylactic cranial irradiation is associated with improved survival following resection for limited stage small cell lung cancer

摘要: Background: Brain metastases are a major cause of mortality in patients with small cell lung cancer (SCLC). Prophylactic cranial irradiation (PCI) may improve survival among that respond to chemotherapy. Less is known about the outcomes PCI following surgical resection SCLC. The purpose this study was determine if who underwent initial SCLC benefit from PCI. Methods: Adult National Cancer Database (NCDB) complete for primary, non-metastatic between 2004 and 2015 were identified. Patients received preoperative chemotherapy or did not receive appropriate adjuvant excluded. grouped by treatment without radiation within 8 months resection. Survival estimated using Kaplan-Meier Cox multivariable analysis, adjusting patient tumor characteristics. Results: A total 859 met inclusion criteria (202 657 not). analysis demonstrated treated had significantly improved compared no (5-year 59% vs. 50%, logrank P=0.0038). Multivariable cox models confirmed decreased hazard death receiving (HR: 0.70, 95% CI: 0.55–0.89, P=0.003). In subset analyses, associated node positive patients, but negative patients. Conclusions: increased lymph nodes appear most, while it remains unclear derive benefit. Further warranted clarify which subsets should be PCI.