QuantiFERON-TB Gold: state of the art for the diagnosis of tuberculosis infection?
作者： Tom G Connell , Molebogeng X Rangaka , Nigel Curtis , Robert J Wilkinson
关键词:
摘要: Tuberculosis (TB) remains a major threat to global health. The recently launched Global Plan Stop 2006–2015 highlights the need for accurate, simple and low-cost diagnostic tests detection of TB infection. For first time in decades, new tools have emerged that may facilitate this goal. discovery Mycobacterium tuberculosis-specific immunodominant antigens has led development interferon γ-release assays been shown high sensitivity specificity disease. This review focuses on QuantiFERON-TB Gold addresses potential strengths limitations current assays, summarizes available evidence their use identifies areas future research development. Although representing an advance diagnostics, with significant impact control, many issues remain unanswered. cost laboratory requirements limit developing countries...
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