The effect of tuberculin skin testing on viral load and anti-mycobacterial immune responses in HIV-1-infected Ugandan adults.
作者： P. B. Namujju , A. M. Elliott , G. Miiro , J. A. G. Whitworth , P. A. Mawa
DOI:
关键词: Immunology 、 Tuberculosis 、 Viral disease 、 Viral load 、 Immunopathology 、 Tuberculin 、 Phytohaemagglutinin 、 Medicine 、 Whole blood 、 Cellular immunity
摘要: OBJECTIVE: To determine whether tuberculin skin testing (TST) is associated with an increase in human immunodeficiency virus (HIV) viral load, and to examine the effect of TST on anti-mycobacterial immune responses. DESIGN: A nested cohort study HIV-1-infected adults. METHOD: Forty-two participants (21 TST-positive 21 TST-negative) from a larger were recruited study. Blood was collected for CD4+ T-cell count, whole blood cultured, plasma saved load. These measurements taken before, 3 days after, months plus after TST. Cytokine responses culture filtrate proteins (CFP) Mycobacterium tuberculosis phytohaemagglutinin (PHA) examined assay. RESULTS: Twenty-nine attended all four visits. No statistically significant change or cytokine response PHA observed at any visit. However, transient interferon-gamma CFP lasting interleukin-5 CFP. CONCLUSION: There appeared be systemic anti-tuberculosis response.
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