Widespread Role for the Flowering-Time Regulators FCA and FPA in RNA-Mediated Chromatin Silencing

作者: I. Baurle , L. Smith , D. C. Baulcombe , C. Dean

DOI: 10.1126/SCIENCE.1146565

关键词:

摘要: The RRM-domain proteins FCA and FPA have previously been characterized as flowering-time regulators in Arabidopsis. We show that they are required for RNA-mediated chromatin silencing of a range loci the genome. At some target loci, promote asymmetric DNA methylation, whereas at others function parallel to methylation. Female gametophytic development early embryonic particularly susceptible malfunctions FPA. propose regulate single low-copy genes interact locus-dependent manner with canonical small interfering RNA-directed methylation pathway common targets.

参考文章(28)
Christophe Maris, Cyril Dominguez, Frédéric H.-T. Allain, The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression FEBS Journal. ,vol. 272, pp. 2118- 2131 ,(2005) , 10.1111/J.1742-4658.2005.04653.X
Olga Pontes, Carey Fei Li, Pedro Costa Nunes, Jeremy Haag, Thomas Ream, Alexa Vitins, Steven E. Jacobsen, Craig S. Pikaard, The Arabidopsis Chromatin-Modifying Nuclear siRNA Pathway Involves a Nucleolar RNA Processing Center Cell. ,vol. 126, pp. 79- 92 ,(2006) , 10.1016/J.CELL.2006.05.031
O. M. Scheid, A. V. Probst, K. Afsar, J. Paszkowski, Two regulatory levels of transcriptional gene silencing in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 13659- 13662 ,(2002) , 10.1073/PNAS.202380499
Yoshiki Habu, Olivier Mathieu, Muhammad Tariq, Aline V Probst, Chotika Smathajitt, Tong Zhu, Jerzy Paszkowski, Epigenetic regulation of transcription in intermediate heterochromatin EMBO Reports. ,vol. 7, pp. 1279- 1284 ,(2006) , 10.1038/SJ.EMBOR.7400835
AJ Herr, MB Jensen, T Dalmay, DC Baulcombe, RNA Polymerase IV Directs Silencing of Endogenous DNA Science. ,vol. 308, pp. 118- 120 ,(2005) , 10.1126/SCIENCE.1106910
Zhixin Xie, Lisa K Johansen, Adam M Gustafson, Kristin D Kasschau, Andrew D Lellis, Daniel Zilberman, Steven E Jacobsen, James C Carrington, Genetic and Functional Diversification of Small RNA Pathways in Plants PLOS Biology. ,vol. 2, ,(2004) , 10.1371/JOURNAL.PBIO.0020104
Zachary Lippman, Bruce May, Cristy Yordan, Tatjana Singer, Rob Martienssen, None, Distinct mechanisms determine transposon inheritance and methylation via small interfering RNA and histone modification. PLOS Biology. ,vol. 1, ,(2003) , 10.1371/JOURNAL.PBIO.0000067
Israel Ausín, Carlos Alonso-Blanco, José A Jarillo, Leonor Ruiz-García, José M Martínez-Zapater, Regulation of flowering time by FVE, a retinoblastoma-associated protein. Nature Genetics. ,vol. 36, pp. 162- 166 ,(2004) , 10.1038/NG1295
Victor Quesada, Richard Macknight, Caroline Dean, Gordon G Simpson, Autoregulation of FCA pre-mRNA processing controls Arabidopsis flowering time. The EMBO Journal. ,vol. 22, pp. 3142- 3152 ,(2003) , 10.1093/EMBOJ/CDG305