EphA4-Mediated Ipsilateral Corticospinal Tract Misprojections Are Necessary for Bilateral Voluntary Movements But Not Bilateral Stereotypic Locomotion

摘要: In this study, we took advantage of the reported role EphA4 in determining contralateral spinal projection corticospinal tract (CST) to investigate effects ipsilateral misprojections on voluntary movements and stereotypic locomotion. Null mutations produce robust CST misprojections, resulting bilateral tracts. We hypothesize that a unilateral limb movement, not locomotor will become movement knock-out mice with CST. However, full knock-outs, interneurons also develop misprojections. Aberrant circuits could thus transform control signals into movements. therefore studied conditional forebrain deletion gene under by Emx1, expressed affects developing but spares brainstem motor pathways circuits. examined two knock-outs targeting during performance locomotion movement: adaptive over obstacles exploratory reaching. found used alternate stepping, hopping, overground locomotion, suggesting normal central pattern generator function supporting our hypothesis minimal involvement moment-to-moment contrast, showed conditions when single are normally produced and, as basis for aberrant control, developed map cortex is driven Therefore, specific change connectivity associated explains movement.