An overview of protein moonlighting in bacterial infection

摘要: We are rapidly returning to a world in which bacterial infections major health issue. Pathogenic bacteria able colonize and cause pathology due the possession of virulence factors such as adhesins, invasins, evasins toxins. These generally specifically evolved proteins with selective actions. It is, therefore, surprising that most human pathogens employ moonlighting factors. Currently, >90 species one or more protein families aid colonization induce disease. organisms 90 these include enzymes glycolytic pathway, tricarboxylic acid (TCA) cycle, hexosemonophosphate shunt, glyoxylate cycle range other metabolic enzymes, proteases, transporters and, also, molecular chaperones protein-folding catalysts. have homologues eukaryotes only proportion employed solely origin. Bacterial can be divided into those single functions multiple additional biological contribute significantly population by some obvious therapeutic targets. Where examined, bind target ligands high affinity. A puzzle is evolutionary mechanism(s) responsible for growing number highly homologous exhibit widely different actions, suggesting lack our understanding mechanism evolution active sites.