The influence of insulin on various enzyme activities in human and rat hepatoma cells.

摘要: 1 Incubation of human and rat hepatoma cells with insulin (1 mU/106 cells) decreases their content adenosine 3′:5′-monophosphate by more than half after 1 h about a quarter 4 h. 2 The activities the ATP-metabolising enzymes, adenylate kinase Mg2+-adenosine triphosphatase are significantly increased within I h. Activity succinate dehydrogenase. lactic dehydrogenase showed no change at either time interval. 3 Insulin markedly stimulated glucose 6-phosphate activity but increase was less apparent. Glutamate contrast not 1,h elevated