Pentoxifylline reduces injury to isolated lungs perfused with human neutrophils.

摘要: Neutrophils and neutrophil-derived oxidants have been implicated in the development of acute lung injury such as that seen adult respiratory distress syndrome (ARDS), bronchopulmonary dysplasia (BPD), animal models injury, including isolated perfused lung. Both oxidant production retention neutrophils are required for this model. Pentoxifylline can reduce from sepsis guinea pig endotoxin-induced neutrophil sequestration dog. It is also known to increase deformability, which may affect pulmonary microvasculature. We evaluated production, lungs, neutrophil-mediated after phorbol myristate acetate (PMA) presence pentoxifylline. (2 mM) significantly reduced Superoxide anion hydrogen peroxide vitro PMA-stimulated when pentoxifylline was dire...