Preventive effect of inhaled nitric oxide and pentoxifylline on ischemia/reperfusion injury after lung transplantation.

摘要: Background The preventive effect of inhaled nitric oxide (NO) and pentoxifylline (PTX) administered during reperfusion has been demonstrated on experimental models lung ischemia/reperfusion (I/R) injury but this strategy is not validated in clinical transplantation. aim study was to assess retrospectively the protective NO PTX after Methods Twenty-three consecutive patients who received (10 ppm) (NO-PTX group) at time were compared with (1) 23 transplanted just before use NO-PTX (control group 23); (2) 95 representing all series did receive 95), respect I/R related complications. In particular, incidence pulmonary reimplantation edema early hemodynamic failure, PaO2/FIO2 ratio as well duration mechanical ventilation 2-month mortality rates compared. Results Reimplantation observed 6/23 (26%) vs. 13/23 (56%) control (P=0.035) 48/95 (50%) (P=0.035). worst first three postoperative days 240-102 mmHg 162+/-88 (P=0.01) 176+/-107 95, respectively. 2.1+/-2.4 7+/-9 (P=0.02) 6+/-7 (P=0.01). rate 4.3% 26% (P=0.04) 21% (P=0.07) Conclusions marked decrease allograft dysfunction two historical groups suggests that given throughout are against setting