Enhanced Tumor Targeting and Antitumor Activity of Gemcitabine Encapsulated Stealth Liposome's

摘要: Introduction: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Gemcitabine new cytotoxic drug but some of limitations while its use likes it suppress the activity Bone marrow i.e. effect on blood forming cells, lower half life-7-18 min.unable deliver by oral & route. Higher dose-1000-1250 mg/m2 require against malignancies. Effective various solid tumor like colon, lungs, breast etc. Several attempt was made enhance efficacy gemcitabine including novel stealth liposomal technology might proves avoids above limitation. Method: A present investigation focuses encapsulation inside vesicle adopting pH gradient methods followed solvent evaporation. The resulting formulation liposomes characterize size, zeta potential sizer along with efficiency centrifugation. optimization carried out statistically 32 factorial design. optimized further subjected vitro antitumor cell line study vivo performance using animal model. Results: comparatively evaluated conventional pure based that effectively retarding % growth than others. Bio distribution profile organs assure prolong circulation maximum concentration even after 24 hrs study. There no sign toxicity administration supported data obtained through studies. Conclusion: final outcomes research improved PEGylation (stealth) also minimize unwanted toxicities associated via route administration.