Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs.
作者： Maria Laura Immordino , Paola Brusa , Flavio Rocco , Silvia Arpicco , Maurizio Ceruti
DOI: 10.1016/J.JCONREL.2004.09.001
关键词: Cytotoxicity 、 Liposome 、 Gemcitabine 、 Biochemistry 、 In vivo 、 Chemistry 、 Prodrug 、 In vitro 、 Pharmacokinetics 、 Metabolite
摘要: … prodrugs in liposomes, where their … in liposomes, was between two- and sevenfold that of free gemcitabine. Encapsulation of long-chain lipophilic prodrugs of gemcitabine in liposomes …
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