The free radical hypothesis of aging: An appraisal of the current status
作者： R. S. Sohal
DOI: 10.1007/BF03324120
关键词:
摘要: The objective of this review article is to assess the current status predictions free radical hypothesis aging, highlighting some controversies surrounding previous assumptions. Topics for discussion include: metabolic rate and oxidative stress molecular damage during antioxidants antioxidant defenses life spans different species, pro-oxidant generation aging. On basis currently available evidence, it concluded that has neither been proven nor disproven. Some earlier assumptions such as intake increases span, or decline with age, are positively correlated longer associated lower autoxidizability, not clearly supportable. Similarly, assumption oxygen radicals govern aging via infliction lacks compelling support. Enough information lift above level speculation yet amassed. Clearly, further studies, which specifically focus on disproving hypothesis, needed confirm its veracity. (Aging Clin. Exp. Res. 5: 3–17, 1993)
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