Palladium-catalyzed tandem allylic substitution/cyclization and cascade hydrosilylated reduction: the influence of reaction parameters and hydrosilanes on the stereoselectivity
作者： Peng-Wei Long , Jian-Xing Xu , Xing-Feng Bai , Zheng Xu , Zhan-Jiang Zheng
DOI: 10.1039/C8RA02995D
关键词:
摘要: To shed light on the influence of reaction parameters palladium-catalyzed tandem allylic alkylation in presence Fei-Phos (a chiral trans-1,2-diaminocyclohexane-derived phosphine ligand), effect different ligands, inorganic or organic bases, Bronsted acids, and other additives asymmetric palladium-catalysed catechol with diacetate was investigated. In this reaction, 2-vinyl-2,3-dihydro-benzo[1,4]dioxin products promising enantioselectivity were achieved good yields. addition, a novel three-component one-pot substitution/cyclization/reduction assisted by methylphenylsilane reported selectivity.
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