MUC gene expression and histogenesis of adenocarcinoma of the stomach.
作者： Shizuki Tsukashita , Ryoji Kushima , Masamichi Bamba , Hiroyuki Sugihara , Takanori Hattori
DOI: 10.1002/IJC.1460
关键词:
摘要: To elucidate the histogenesis of adenocarcinomas stomach, we examined MUC gene expression in gland-forming intramucosal neoplastic lesions. Eighty tumors were histopathologically assigned to 1 following 3 groups based upon Vienna classification: group A (low-grade adenoma/dysplasia), B (high-grade adenoma/dysplasia) and C (intramucosal carcinoma). Immunohistochemic staining was performed with monoclonal antibodies against MUC2 (goblet cell mucin), MUC5AC (gastric-foveolar MUC6 (pyloric-gland mucin) CD10 (brush border). Ki-67 also carried out. An obvious difference existed between lesions those C. The majority strongly expressed intestinal markers which proliferating zones formed but generally no gastric markers, whereas more than 50% markers. These findings suggest that are a stable phenotype, phenotypically genotypically unstable, indicating adenoma-carcinoma sequence is not major pathway, instead arise de novo. © 2001 Wiley-Liss, Inc.
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