Miniaturized pre-clinical cancer models as research and diagnostic tools

摘要: Cancer is one of the most common causes death worldwide. Consequently, important resources are directed towards bettering treatments and outcomes. difficult to treat due its heterogeneity, plasticity frequent drug resistance. New treatment strategies should strive for personalized approaches. These target neoplastic and/or activated microenvironmental heterogeneity without triggering resistance spare host cells. In this review, putative use increasingly physiologically relevant microfabricated cell-culturing systems intended development discussed. There two main reasons miniaturized systems. First, scaling down model size allows high control cues enabling more predictive Second, miniaturization reduces reagent consumption, thus facilitating combinatorial approaches with little effort enables application scarce materials, such as patient-derived samples. This review aims give an overview state-of-the-art while predicting their in cancer development.