Cellular bioenergetics as a target for obesity therapy
作者： Yu-Hua Tseng , Aaron M. Cypess , C. Ronald Kahn
DOI: 10.1038/NRD3138
关键词:
摘要: Most current obesity therapies aim to reduce calorific intake or absorption and are limited by poor efficacy unpleasant side effects. Here, Tseng colleagues discuss the therapeutic potential of alternative approach increasing cellular energy expenditure, principally stimulating adaptive thermogenesis, prevent treat this disorder.
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S. Cunningham, P. Leslie, D. Hopwood, P. Illingworth, R. T. Jung, D. G. Nicholls, N. Peden, J. Rafael, E. Rial, The characterization and energetic potential of brown adipose tissue in man Clinical Science. ,vol. 69, pp. 343- 348 ,(1985) , 10.1042/CS0690343
E A Newsholme, B Crabtree, Substrate cycles in metabolic regulation and in heat generation. Biochemical Society symposium. pp. 61- 109 ,(1976)
N. J. Rothwell, M. J. Stock, Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favour Clinical Science. ,vol. 64, pp. 19- 23 ,(1983) , 10.1042/CS0640019
Joint Fao, Human energy requirements : report of a Joint FAO/WHO/UNU Expert Consultation : Rome, 17-24 October 2001 Food and Agricultural Organization of the United Nations. ,(2004)
Jose C Appolinario, Jo??o R Bueno, Walmir Coutinho, Psychotropic drugs in the treatment of obesity: what promise? CNS Drugs. ,vol. 18, pp. 629- 651 ,(2004) , 10.2165/00023210-200418100-00002
M. E. J. Lean, W. P. T. James, G. Jennings, P. Trayhurn, Brown adipose tissue uncoupling protein content in human infants, children and adults. Clinical Science. ,vol. 71, pp. 291- 297 ,(1986) , 10.1042/CS0710291
Caroline Gosselin, Guylaine Cote, Weight loss maintenance in women two to eleven years after participating in a commercial program: a survey. BMC Women's Health. ,vol. 1, pp. 2- 2 ,(2001) , 10.1186/1472-6874-1-2
Nicholas M. Morton, Jonathan R. Seckl, 11beta-hydroxysteroid dehydrogenase type 1 and obesity. Frontiers of Hormone Research. ,vol. 36, pp. 146- 164 ,(2008) , 10.1159/000115363
J M Heaton, The distribution of brown adipose tissue in the human. Journal of Anatomy. ,vol. 112, pp. 35- 39 ,(1972)
Fahumiya Samad, Koji Yamamoto, Manjula Pandey, David J. Loskutoff, Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Molecular Medicine. ,vol. 3, pp. 37- 48 ,(1997) , 10.1007/BF03401666