Animal Models for Manipulation of Thermogenesis

摘要: Abstract Body weight is determined by the balance between energy intake and expenditure. Obesity ensues when exceeds that of To date, majority pharmaco-therapies to control body have been directed towards appetitive limb this equation. Very few anti-obesity agents target manipulation The recent unequivocal demonstration functional brown adipose tissue present in adult humans has sparked a great deal interest developing means exploit thermogenesis weight. Thermogenesis defined as dissipation through production heat occurs specialised tissues including skeletal muscle. This chapter will highlight number animal models are currently utilised effort understand mechanisms underpin thermogenesis. It describe muscle well detailing role determining susceptibility obesity distinct models.