Timolol reduces IOP in normal NZW rabbits during the dark only.

摘要: The role of beta-adrenergic receptors in mediating the circadian rhythm intraocular pressure was examined by determining effect on timolol applied topically at different times during cycle to New Zealand White rabbits entrained alternating 12 hr periods light and dark. Timolol lowered when dark but not phase cycle. did lower animals after cervical ganglionectomy. These results are consistent with idea that participate pressure, suggest endogenous agonists released adrenergic nerves eye stimulate ocular increase rabbits. Invest Ophthalmol Vis Sci 31:715-721,1990 There is a (IOP) rabbits; IOP low high phase. 1 " 3 A aqueous flow makes major contribution IOP. 14 9 Adrenergic input required for complete expression IOP; ganglionectomy (CGX) or decentralization (DX) decrease 310 experiments reported here were designed determine whether To do this topical application timolol, nonselective antagonist which decreases flow,"" 19 (NZW)