Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway.
作者： Takeshi Onizuka , Shinsuke Yuasa , Dai Kusumoto , Kenichiro Shimoji , Toru Egashira
DOI: 10.1016/J.YJMCC.2011.11.010
关键词:
摘要: The efficient induction of cardiomyocyte differentiation from embryonic stem (ES) cells is crucial for cardiac regenerative medicine. Although Wnts play important roles in development, complex questions remain as to when, how and what types are involved cardiogenesis. We found that Wnt2 was strongly up-regulated during ES cells. Therefore, we investigated when acts cardiogenesis cell differentiation. expressed the early developing murine heart. applied this expression pattern differentiation, elucidate function knockdown revealed intrinsic essential Moreover, exogenous increased Interestingly, effects on addition were temporally restricted. During cells, didn't activate canonical Wnt pathway but utilizes JNK/AP-1 which required Therefore conclude plays strong positive stage-specific role through non-canonical
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sci-hub.se 参考文章(49)
Jun K. Yamashita, Makoto Takano, Mina Hiraoka‐Kanie, Chikashi Shimazu, Yan Peishi, Kentoku Yanagi, Akiko Nakano, Emi Inoue, Fumiyo Kita, Shin‐Ichi Nishikawa, Prospective identification of cardiac progenitors by a novel single cell-based cardiomyocyte induction The FASEB Journal. ,vol. 19, pp. 1534- 1536 ,(2005) , 10.1096/FJ.04-3540FJE
Alexander Alexandrovich, Matthew Arno, Roger K. Patient, Ajay M. Shah, John A. Pizzey, Alison C. Brewer, Wnt2 is a direct downstream target of GATA6 during early cardiogenesis. Mechanisms of Development. ,vol. 123, pp. 297- 311 ,(2006) , 10.1016/J.MOD.2006.02.002
Toru Egashira, Kojiro Yae, Dai Kusumoto, Hikari Nakata, Shugo Tohyama, Hisayuki Hashimoto, Masaki Kodaira, Yohei Okada, Hiroyuki Seimiya, Noemi Fusaki, Mamoru Hasegawa, Keiichi Fukuda, Tomohisa Seki, Shinsuke Yuasa, Mayumi Oda, Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. Cell Stem Cell. ,vol. 7, pp. 11- 14 ,(2010) , 10.1016/J.STEM.2010.06.003
S. Ueno, G. Weidinger, T. Osugi, A. D. Kohn, J. L. Golob, L. Pabon, H. Reinecke, R. T. Moon, C. E. Murry, Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 9685- 9690 ,(2007) , 10.1073/PNAS.0702859104
C. Kwon, J. Arnold, E. C. Hsiao, M. M. Taketo, B. R. Conklin, D. Srivastava, Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 10894- 10899 ,(2007) , 10.1073/PNAS.0704044104
Shinsuke Yuasa, Yuji Itabashi, Uichi Koshimizu, Tomofumi Tanaka, Keijiro Sugimura, Masayoshi Kinoshita, Fumiyuki Hattori, Shin-ichi Fukami, Takuya Shimazaki, Hideyuki Okano, Satoshi Ogawa, Keiichi Fukuda, Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nature Biotechnology. ,vol. 23, pp. 607- 611 ,(2005) , 10.1038/NBT1093
Hong Wang, Jennifer B. Gilner, Victoria L. Bautch, Da-Zhi Wang, Brandon J. Wainwright, Suzanne L. Kirby, Cam Patterson, Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies Journal of Biological Chemistry. ,vol. 282, pp. 782- 791 ,(2007) , 10.1074/JBC.M606610200
Kenichiro Shimoji, Shinsuke Yuasa, Takeshi Onizuka, Fumiyuki Hattori, Tomofumi Tanaka, Mie Hara, Yohei Ohno, Hao Chen, Toru Egasgira, Tomohisa Seki, Kojiro Yae, Uichi Koshimizu, Satoshi Ogawa, Keiichi Fukuda, G-CSF promotes the proliferation of developing cardiomyocytes in vivo and in derivation from ESCs and iPSCs. Cell Stem Cell. ,vol. 6, pp. 227- 237 ,(2010) , 10.1016/J.STEM.2010.01.002
Martin Hooper, Kate Hardy, Alan Handyside, Susan Hunter, Marilyn Monk, HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature. ,vol. 326, pp. 292- 295 ,(1987) , 10.1038/326292A0
Martha J Marvin, Giuliana Di Rocco, Aaron Gardiner, Sara M Bush, Andrew B Lassar, Inhibition of Wnt activity induces heart formation from posterior mesoderm Genes & Development. ,vol. 15, pp. 316- 327 ,(2001) , 10.1101/GAD.855501