Biological responses to hydroxyapatite surfaces deposited via a co-incident microblasting technique.

摘要: Hydroxyapatite (HA) is routinely used as a coating on range of press-fit (cementless) orthopaedic implants to enhance their osseointegration. The standard plasma spraying method deposit HA surface layer such often contains unwanted crystal phases that can lead delamination in vivo. Consequently, there has been continuous drive develop alternate modification technologies eliminate the problems caused by non-optimal process. In this study two methods for creating metal alloys employ micro-blasting have evaluated determine if inclusion an abrasive agent vitro and vivo performance modified surface. first employs direct using media, while second simultaneous blasting with alumina coincident dopant. Whereas, both were found produce which was enriched HA, respective microstructures created significantly different. Detailed characterisation revealed use produced disruption without producing detectable incorporation particles. Roughening way breached passivating oxide sites subsequently provided impregnation, mechanical interlocking chemical bonding HA. co-incident dopant resulted stable demonstrated enhanced osteoblast attachment viability compared response alone or substrate control. Implantation rabbit model confirmed promoted formation early stage lamellar bone growth.