Opioid System and Alzheimer’s Disease

摘要: The opioid system may be involved in the pathogenesis of AD, including cognitive impairment, hyperphosphorylated tau, Aβ production, and neuroinflammation. Opioid receptors influence regulation neurotransmitters such as acetylcholine, norepinephrine, GABA, glutamate, serotonin which have been implicated AD. has a close relation with generation since dysfunction retards endocytosis degradation BACE1 γ-secretase upregulates γ-secretase, subsequently, production Aβ. Conversely, activation increases downregulates limiting (opioid peptides) contribute to hyperphosphorylation tau neuroinflammation, accounts for degeneration cholinergic neurons impairment. Thus, is potentially related AD pathology very attractive drug target novel pharmacotherapies