Effect of sodium selenite and vitamin E on the renal cortex in rats: an ultrastructure study.
作者： Adel M. Hussein , Hamid A. Saleh , Mustafa H.N.
DOI: 10.1016/J.TICE.2014.03.002
关键词:
摘要: a b s t r c This study examined the use of vitamin E to alleviate toxic effects sodium selenite. Adult male albino rats (n = 50) was divided into five groups. Group 1 control, Groups 2 and 4 were treated with selenite (2 mg/kg) for weeks, respectively, 3 5 (100 respectively. Renal tissues studied using anti-BCL2 ultrastructurally. Positive Bax immunoreactivity detected after more positive weeks nearly all groups improved co-administration E. Ultrastructural revealed lesions in Bowman’s capsule proximal convoluted tubules. The submicroscopic damage necrosis cortical structures After cellular changes seen, such as vacuolation moderate degeneration cells, widening urinary space scattered through cortex loss details, formation apical buds, degeneration, rupture. Present findings disclosed an ameliorative effect adding selenite-induced tissues. Clinically, it is advised add avoid selenium overdose hazards. © 2014 Elsevier Ltd. All rights reserved.
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