Clinical Trials of Dementia With Lewy Bodies and Parkinson’s Disease Dementia

摘要: Despite the frequency and importance of dementia associated with Parkinson’s disease (PDD) Lewy bodies (DLB), there is relatively little evidence on which to base treatment. Evidence from meta-analysis suggests that rivastigmine can improve cognition functioning in PDD also reduce risk falling. There supporting its use DLB. Recent memantine may be effective, particularly for PDD, although more conflicting. Memantine parkinsonism dyskinesias. Few clinical trials PD without exist, but preliminary atomoxetine, memantine, piribedil. a lack systematic treatment visual hallucinations depression In addition, need studies whether potentially disease-modifying agents prevent or delay progression PD.