Therapeutic exploitation of the p53 pathway

摘要: Analysis of the gene encoding p53 could serve to evaluate effectiveness a cancer treatment. Mutations in this occur half all human cancers, and regulation protein is defective variety others. Novel strategies that exploit our knowledge function are being actively investigated. Strategies directed at treating tumours have mutations include therapy, viruses only replicate deficient cells, search for small molecules reactivate mutant p53. Potentiating non-genotoxic way express wildtype can be achieved by inhibiting expression Mdm2 or viral oncoproteins.