High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation

作者: Jiajun Ju , Xiangfang Peng , Keqing Huang , Lengwan Li , Xianhu Liu

DOI: 10.1016/J.POLYMER.2019.121707

关键词:

摘要: Porous poly (l-lactic acid)(PLLA)-based tissue engineering scaffolds have gained growing interests due to their unique structures and properties. However, the simple and green fabrication of PLLA-based scaffolds with uniform and interconnected pore structure, good degradability and hydrophobicity, and excellent biocompatibility remain a major challenge. Herein, we developed a facile, cost-effective and eco-friendly structural manipulation processing with supercritical carbon dioxide (Sc-CO 2) foaming technique to prepare porous …

参考文章(58)
Chunmei Zhang, Liwei Wang, Tianliang Zhai, Xinchao Wang, Yi Dan, Lih-Sheng Turng, The surface grafting of graphene oxide with poly(ethylene glycol) as a reinforcement for poly(lactic acid) nanocomposite scaffolds for potential tissue engineering applications. Journal of The Mechanical Behavior of Biomedical Materials. ,vol. 53, pp. 403- 413 ,(2016) , 10.1016/J.JMBBM.2015.08.043
Dajiong Fu, Tairong Kuang, Feng Chen, Ly James Lee, Xiangfang Peng, Fabrication of high strength PA6/PP blends with pressure-induced-flow processing Materials Chemistry and Physics. ,vol. 164, pp. 1- 5 ,(2015) , 10.1016/J.MATCHEMPHYS.2015.08.043
Hui Wang, Jing Di, Yubing Sun, Jianping Fu, Zengyan Wei, Hiroshi Matsui, Alejandra del C. Alonso, Shuiqin Zhou, Biocompatible PEG-Chitosan@Carbon Dots Hybrid Nanogels for Two-Photon Fluorescence Imaging, Near-Infrared Light/pH Dual-Responsive Drug Carrier, and Synergistic Therapy Advanced Functional Materials. ,vol. 25, pp. 5537- 5547 ,(2015) , 10.1002/ADFM.201501524
Dachao Li, Dajiong Fu, Ying-Chieh Yen, Avraham Benatar, Xiangfang Peng, Debbie Y. Chiu, L. James Lee, Ultrasound-assisted-pressure-induced-flow leading to superior polymer/carbon nanotube composites and foams Polymer. ,vol. 80, pp. 237- 244 ,(2015) , 10.1016/J.POLYMER.2015.10.058
Bin-Yi Chen, Xin Jing, Hao-Yang Mi, Haibin Zhao, Wen-Hao Zhang, Xiang-Fang Peng, Lih-Sheng Turng, Fabrication of polylactic acid/polyethylene glycol (PLA/PEG) porous scaffold by supercritical CO2 foaming and particle leaching Polymer Engineering & Science. ,vol. 55, pp. 1339- 1348 ,(2015) , 10.1002/PEN.24073
K. Rezwan, Q.Z. Chen, J.J. Blaker, Aldo Roberto Boccaccini, BIODEGRADABLE AND BIOACTIVE POROUS POLYMER/INORGANIC COMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING Biomaterials. ,vol. 27, pp. 3413- 3431 ,(2006) , 10.1016/J.BIOMATERIALS.2006.01.039
Sandra Pina, Joaquim M Oliveira, Rui L Reis, None, Natural-Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review Advanced Materials. ,vol. 27, pp. 1143- 1169 ,(2015) , 10.1002/ADMA.201403354
Hironori Marubayashi, Satoshi Akaishi, Shuichi Akasaka, Shigeo Asai, Masao Sumita, Crystalline Structure and Morphology of Poly(l-lactide) Formed under High-Pressure CO2 Macromolecules. ,vol. 41, pp. 9192- 9203 ,(2008) , 10.1021/MA800766H
Wenhao Zhang, Binyi Chen, Haibin Zhao, Peng Yu, Dajiong Fu, Jinsong Wen, Xiangfang Peng, None, Processing and characterization of supercritical CO2 batch foamed poly(lactic acid)/poly(ethylene glycol) scaffold for tissue engineering application Journal of Applied Polymer Science. ,vol. 130, pp. 3066- 3073 ,(2013) , 10.1002/APP.39523