Melatonin. A possible role in pathogenesis of adolescent idiopathic scoliosis.
作者： Masafumi Machida , Jean Dubousset , Yasuhide Imamura , Yukiko Miyashita , Thoru Yamada
DOI: 10.1097/00007632-199605150-00005
关键词:
摘要: Study Design. The serum melatonin levels during 24-hour periods were compared between patients with idiopathic and age-matched normal control subjects. Objective. To find if the deficiency may have some role for progression or etiology of scoliosis in humans. Summary Background Data. Experimentally induced chicken by pinealectomy can be attributed to defect metabolism. Methods. Blood samples correlated every 3 hours periods, measured statistically analyzed. Results. level melatonin, integrated concentration through 24 night time (0:00 AM-6:00 AM), who had progressive curve (more than 10° previous 12 months) was significantly lower a stable (less subjects (P < 0.05). Conclusion. study suggests that synthesis metabolism crucial regulating spine growth. appears useful predictor curvature scoliosis.
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sci-hub.se 参考文章(53)
DENNIS K. COLLIS, IGNACIO V. PONSETI, Long-term follow-up of patients with idiopathic scoliosis not treated surgically Journal of Bone and Joint Surgery, American Volume. ,vol. 51, pp. 425- 445 ,(1969) , 10.2106/00004623-196951030-00001
RICHARD H. FISHER, The Kutler method of repair of finger-tip amputations. Journal of Bone and Joint Surgery, American Volume. ,vol. 49, pp. 317- 321 ,(1967) , 10.2106/00004623-196749020-00008
Dohrman Sc, Pedrini Va, Ponseti, Glycosaminoglycans of intervertebral disc in idiopathic scoliosis. Journal of Laboratory and Clinical Medicine. ,vol. 82, pp. 938- 950 ,(1973)
Shiro Kakiuchi, Reiko Yamazaki, Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain studies on cyclic 3',5'-nucleotide phosphodiesterase (3). Biochemical and Biophysical Research Communications. ,vol. 41, pp. 1104- 1110 ,(1970) , 10.1016/0006-291X(70)90199-3
P Agre, K Gardner, V Bennett, Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes. Journal of Biological Chemistry. ,vol. 258, pp. 6258- 6265 ,(1983) , 10.1016/S0021-9258(18)32401-3
D M Watterson, W G Harrelson, P M Keller, F Sharief, T C Vanaman, Structural similarities between the Ca2+-dependent regulatory proteins of 3':5'-cyclic nucleotide phosphodiesterase and actomyosin ATPase. Journal of Biological Chemistry. ,vol. 251, pp. 4501- 4513 ,(1976) , 10.1016/S0021-9258(17)33231-3
W. F. ENNEKING, PAUL HARRINGTON, Pathological Changes in Scoliosis Journal of Bone and Joint Surgery, American Volume. ,vol. 51, pp. 165- 184 ,(1969) , 10.2106/00004623-196951010-00014
Julius Axelrod, Richard J. Wurtman, Lincoln T. Potter, THE UPTAKE OF H3-MELATONIN IN ENDOCRINE AND NERVOUS TISSUES AND THE EFFECTS OF CONSTANT LIGHT EXPOSURE Journal of Pharmacology and Experimental Therapeutics. ,vol. 143, pp. 314- 318 ,(1964)
SETSURO EBASHI, AYAKO KODAMA, FUMIKO EBASHI, Troponin. I. Preparation and physiological function. Journal of Biochemistry. ,vol. 64, pp. 465- 477 ,(1968) , 10.1093/OXFORDJOURNALS.JBCHEM.A128918
M Machida, J Dubousset, Y Imamura, T Iwaya, T Yamada, J Kimura, Role of melatonin deficiency in the development of scoliosis in pinealectomised chickens Journal of Bone and Joint Surgery-british Volume. ,vol. 77, pp. 134- 138 ,(1995) , 10.1302/0301-620X.77B1.7822371