Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response.

R. Pinkas-Kramarski, L. Soussan, H. Waterman, G. Levkowitz, I. Alroy, L. Klapper, S. Lavi, R. Seger, B. J. Ratzkin, M. Sela, Y. Yarden, Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. The EMBO Journal. ,vol. 15, pp. 2452- 2467 ,(1996) , 10.1002/J.1460-2075.1996.TB00603.X

Adi F. Gazdar, Shinichi Toyooka, Kazunori Tsukuda, Mitsune Tanimoto, Masahiro Tabata, Kouichi Ichimura, Masaaki Yano, Toshihide Tsuda, Hisayuki Shigematsu, Hiroshi Date, Kunitoshi Tomii, Nobuyoshi Shimizu, Hiroshi Ueoka, Motoi Aoe, Masaki Tokumo, Katsuyuki Kiura, The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non–Small Cell Lung Cancers Clinical Cancer Research. ,vol. 11, pp. 1167- 1173 ,(2005)

Ming-Sound Tsao, Akira Sakurada, Jean-Claude Cutz, Chang-Qi Zhu, Suzanne Kamel-Reid, Jeremy Squire, Ian Lorimer, Tong Zhang, Ni Liu, Manijeh Daneshmand, Paula Marrano, Gilda da Cunha Santos, Alain Lagarde, Frank Richardson, Lesley Seymour, Marlo Whitehead, Keyue Ding, Joseph Pater, Frances A. Shepherd, Erlotinib in lung cancer - molecular and clinical predictors of outcome. The New England Journal of Medicine. ,vol. 353, pp. 133- 144 ,(2005) , 10.1056/NEJMOA050736

Carolyn M. Discafani, Marion L. Carroll, M.Brawner Floyd, Irwin J. Hollander, Zaheed Husain, Bernard D. Johnson, Douglas Kitchen, Michael K. May, Madhu S. Malo, Albert A. Minnick, Ramaswamy Nilakantan, Ru Shen, Yu-Fen Wang, Allan Wissner, Lee M. Greenberger, Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with In Vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785) Biochemical Pharmacology. ,vol. 57, pp. 917- 925 ,(1999) , 10.1016/S0006-2952(98)00356-6

Hidefumi Sasaki, Katsuhiko Endo, Minoru Takada, Masaaki Kawahara, Naoto Kitahara, Hisaichi Tanaka, Meinoshin Okumura, Akihide Matsumura, Keiji Iuchi, Tomoya Kawaguchi, Osamu Kawano, Haruhiro Yukiue, Tomoki Yokoyama, Motoki Yano, Yoshitaka Fujii, EGFR exon 20 insertion mutation in Japanese lung cancer Lung Cancer. ,vol. 58, pp. 324- 328 ,(2007) , 10.1016/J.LUNGCAN.2007.06.024

Kouki Ohtsuka, Hiroaki Ohnishi, Go Furuyashiki, Hiroshi Nogami, Yoshihiko Koshiishi, Akiko Ooide, Satsuki Matsushima, Takashi Watanabe, Tomoyuki Goya, Clinico-Pathological and Biological Significance of Tyrosine Kinase Domain Gene Mutations and Overexpression of Epidermal Growth Factor Receptor for Lung Adenocarcinoma Journal of Thoracic Oncology. ,vol. 1, pp. 787- 795 ,(2006) , 10.1016/S1556-0864(15)30407-X

Takayuki Kosaka, Yasushi Yatabe, Hideki Endoh, Kimihide Yoshida, Toyoaki Hida, Masahiro Tsuboi, Hirohito Tada, Hiroyuki Kuwano, Tetsuya Mitsudomi, Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib Clinical Cancer Research. ,vol. 12, pp. 5764- 5769 ,(2006) , 10.1158/1078-0432.CCR-06-0714

Jin-Yuan Shih, Chien-Hung Gow, Chong-Jen Yu, Chih-Hsin Yang, Yih-Leong Chang, Meng-Feng Tsai, Ya-Chieh Hsu, Kuan-Yu Chen, Wen-Pin Su, Pan-Chyr Yang, Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced nonsmall cell lung cancer. International Journal of Cancer. ,vol. 118, pp. 963- 969 ,(2006) , 10.1002/IJC.21458

Jin-Yuan Shih, Chien-Hung Gow, Pan-Chyr Yang, EGFR Mutation Conferring Primary Resistance to Gefitinib in Non–Small-Cell Lung Cancer The New England Journal of Medicine. ,vol. 353, pp. 207- 208 ,(2005) , 10.1056/NEJM200507143530217

Hajime Asahina, Koichi Yamazaki, Ichiro Kinoshita, Hiroshi Yokouchi, Hirotoshi Dosaka-Akita, Masaharu Nishimura, Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L Lung Cancer. ,vol. 54, pp. 419- 422 ,(2006) , 10.1016/J.LUNGCAN.2006.09.005