Monoclonal antibody therapy of human gliomas: current status and future approaches.
作者： Carol J. Wikstrand , Ilkcan Cokgor , John H. Sampson , Darell D. Bigner
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摘要: The development of immunotherapeutic protocols for the treatment human CNS neoplasia over past two decades has been impressive. Several crucial aspects have defined, characterized, and in many cases, optimized (Wikstrand CJ, Zalutsky MR, Bigner DD: In: Liau LM, DD (eds) Brain Tumor Immunotherapy. Humana Press (in press), 2000). Specific Mabs or constructs reacting with targetable antigens are currently available clinical trial. In addition, additional under study (angiogenesis-related markers, developmentally associated medulloblastoma such as L1, identification new targets by SAGE, just its infancy, will provide a veritable library therapy. molecular engineering affinity maturation techniques being applied to Mab fragment optimization already rapidly effective generating variety appropriate trial; experience is accrued various prospectively available, optimal targeting multitude be possible.
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