Loss of FHIT protein expression correlates with disease progression and poor differentiation in gastric cancer

摘要: The fragile histidine triad (FHIT) gene has recently been proposed as being a tumor suppressor gene. FHIT deletions or aberrant transcripts have identified in variety of human malignancies, including gastric carcinomas, suggesting that may play key role development. However, the clinical impact mutations carcinogenesis is still debated. Our purpose was to investigate whether expression primary carcinoma associated with histological type, grade stage tumor. We analyzed well-characterized set 137 cancers. protein evaluated mucosal samples, both from and tumor-free areas by immunohistochemistry. Furthermore, subgroup 30 patients, mRNA assessed nested RT-PCR. Absent reduced correlated significantly diffuse type (P<0.0001), poor differentiation advanced (P<0.0001) cancer. In contrast, strongly expressed uniformly distributed areas. absent altered poorly differentiated carcinomas. These results show related grade, suggest be considered potential prognostic factor