Beyond CDH1 Mutations: Causes of Hereditary Diffuse Gastric Cancer

摘要: Since highly penetrant CDH1 mutations were described in hereditary diffuse gastric cancer, such mutants have attributed to roughly 40 % of cases. However, the molecular basis remaining 60 families, defined by clinical parameters, remains be determined. Significant advances sequencing technologies past several years improved all aspects gene discovery; including accuracy and analysis data, speed with which data is analyzed overall cost sequencing. Specifically, progress high-throughput methodologies that allow for more targeted interesting genes, along ability sequence many samples a single run, account considerable breakthroughs made disease research, cancer. To this day, most significant attributing familial patterns utilizing latest next generation examining non-CDH1 carrying researchers hope identify gene(s) these cases at faster efficient rate.