Multimodal particles, methods and uses thereof

摘要: The present disclosure, among other things, provides a composition of particle including substrate; at least first condensation layer comprising dopant entity; and second entity. In some embodiments, different entities are included in layers. such or comprise detectable entities. This, provided technologies achieve multi-modality particles. Among the many advantages include ability to image particles by plurality distinct imaging modalities and/or contexts (e.g., pre-surgical, intraoperative post-surgical environments). invention methods that single administration subject, followed steps administered particles, which may utilize be performed times environments.