Prioritization of NTP reproductive toxicants for field studies
作者： William J Moorman , Heinz W Ahlers , Robert E Chapin , George P Daston , Paul M.D Foster
DOI: 10.1016/S0890-6238(00)00089-7
关键词:
摘要: Population studies that evaluate human reproductive impairment are time consuming, expensive, logistically difficult, and with limited resources must be prioritized to effectively prevent the adverse health effects in humans. Interactions among scientists, unions, industry can serve identify populations exposed potential hazards develop strategies apply appropriate controls. This report describes a systematic method for prioritizing chemicals may need field studies. Rodent toxicants identified from National Toxicology Program (NTP) Reproductive Assessment by Continuous Breeding (RACB) protocol were on basis of potency toxic effect population at risk. model prioritization links NTP findings data Occupational Exposure Survey (NOES) Hazardous Substance Data Base (HSDB) or High Production Volume Chemical Database (HPVC) prioritize their impact worker populations. The highest priority study were: dibutyl phthalate, boric acid, tricresyl phosphate, N,N-dimethylformamide.
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sci-hub.se 参考文章(10)
G W Lucier, A Schecter, Human exposure assessment and the National Toxicology Program. Environmental Health Perspectives. ,vol. 106, pp. 623- 627 ,(1998) , 10.1289/EHP.106-1533173
Marcus M. Key, Occupational diseases : a guide to their recognition U.S. Dept. of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health : for sale by the Supt. of Docs., U.S. Govt. Print. Off.. ,(1977)
James M. Donald, Laurie E. Monserrat, Kim Hooper, Steven A. Book, Gerald F. Chernoff, Prioritizing candidate reproductive/developmental toxicants for evaluation. Reproductive Toxicology. ,vol. 6, pp. 99- 108 ,(1992) , 10.1016/0890-6238(92)90027-Q
Victoria E. Wells, T.M. Schnorr, W.E. Halperin, NIOSH selection of chemicals and study publications: setting priorities for reproductive research. Reproductive Toxicology. ,vol. 2, pp. 289- 290 ,(1988) , 10.1016/0890-6238(88)90033-0
John Jankovic, Frances Drake, A screening method for occupational reproductive health risk. American Industrial Hygiene Association Journal. ,vol. 57, pp. 641- 649 ,(1996) , 10.1080/15428119691014701
J D Johnston, G G Jamieson, S Wright, Reproductive and developmental hazards and employment policies. Occupational and Environmental Medicine. ,vol. 49, pp. 85- 94 ,(1992) , 10.1136/OEM.49.2.85
Robert E. Chapin, Richard A. Sloane, Joseph K. Haseman, The Relationships among Reproductive Endpoints in Swiss Mice, Using the Reproductive Assessment by Continuous Breeding Database Toxicological Sciences. ,vol. 38, pp. 129- 142 ,(1997) , 10.1093/TOXSCI/38.2.129
R E Chapin, R A Sloane, Reproductive assessment by continuous breeding: evolving study design and summaries of ninety studies. Environmental Health Perspectives. ,vol. 105, pp. 199- 205 ,(1997) , 10.1289/EHP.97105S1199
T Graham, N Lessin, F Mirer, A labor perspective on workplace reproductive hazards: past history, current concerns, and positive directions. Environmental Health Perspectives. ,vol. 101, pp. 199- 204 ,(1993) , 10.1289/EHP.93101S2199
Jorma Rantanen, Priority setting and evaluation as tools for planning research strategy. Scandinavian Journal of Work, Environment & Health. ,vol. 18, pp. 5- 7 ,(1992)