Y:X sperm ratio in boron-exposed men.
作者： W. A. Robbins , F. Wei , D. A. Elashoff , G. Wu , L. Xun
DOI: 10.2164/JANDROL.107.003541
关键词:
摘要: Several epidemiologic investigations have shown shifts in sex ratios at birth toward females populations with relatively high boron exposure. To investigate the paternal origin of these shifts, we assayed sperm Y:X ratio men exposed to a range environmental and workplace boron. Participants included 63 workers industry: 39 living an area but not employed industry, 44 controls low Total daily exposure was calculated as sum 24-hour duplicate food fluid intakes plus personal air sampling for inhalable dust. Internal dose measured blood, urine, semen. Sperm were analyzed by fluorescence situ hybridization Y- versus X-bearing cells. Potential confounders identified using questionnaire. correlated internal (Pearson correlation total blood = 0.63, P < .0001; semen 0.80, .001; urine 0.79, .0001). Linear regression logged biologic fluids on significant .02, .0003, .005. Additionally, when subjects categorized group, decreased found compared environment (P Exogenous or exposures associated decreases sperm. This may explain earlier findings from us others showing changes offspring
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