Derivation of an occupational exposure limit for inorganic borates using a weight of evidence approach

摘要: Abstract Inorganic borates are encountered in many settings worldwide, spurring international efforts to develop exposure guidance (US EPA, 2004; WHO, 2009; ATSDR, 2010) and occupational limits (OEL) (ACGIH, 2005; MAK, 2011). We derived an updated OEL reflect new data current risk assessment frameworks. assessed toxicity epidemiology on inorganic identify relevant adverse effects. International frameworks (IPCS, 2005, 2007) were used evaluate endpoint candidates: reproductive toxicity, developmental sensory irritation. For each endpoint, a preliminary was adjusted based consideration of toxicokinetics, toxicodynamics, other uncertainties. Selection the point departures (PODs) is supported by dose–response modeling. Developmental most sensitive systemic effect. An 1.6 mg B/m 3 estimated for this effect POD 63 mg B/m with uncertainty factor (UF) 40. Sensory irritation considered be portal entry. 1.4 mg B/m identified UF 1. as 8-h time-weighted average (TWA) recommended.