Blunted autonomic reactivity to pharmacological panic challenge under long-term escitalopram treatment in healthy men.

摘要: Background: Central serotonergic pathways influence brain areas involved in vagal cardiovascular regulation and, thereby, sympathetic efferent activity. Selective serotonin reuptake inhibitors (SSRIs) affect multiple pathways, including central autonomic pathways. However, only a few studies have assessed SSRI-mediated effects on reactivity healthy individuals using heart rate variability (HRV). Methods: The present study the of long-term treatment with escitalopram (ESC) to an intravenous application 50 µg cholecystokinin tetrapeptide (CCK-4) 30 young men double-blind, placebo (PLA)-controlled, randomized, within-subject cross-over design. Main outcome measures were time- and frequency-domain HRV parameters, at both baseline immediately after CCK-4 application. Results: Results showed substantial for × challenge interaction respect ( p < 0.001; pη2 = 0.499), SDNN 576), RMSSD 0.015; 194), NN50% 0.008; 0.224), LF% (p 0.014; 0.196), moderate HF% 0.099; 0.094), PLA subjects showing higher increase HR decrease RMSSD, NN50, LF HF than ESC condition. Thus, significantly blunted CCK-4. Secondary analysis indicated no effect 5-HTTLPR polymorphism CCK-4-induced response. Conclusions: Our results support findings suggesting SSRI provide evidence that is associated men.