The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers.

摘要: Rationale: In therapeutic use, amitriptyline, reboxetine and citalopram have all been associated with apparent anticholinergic-like side effects (dry mouth, constipation, etc.), despite the very low antimuscarinic activity of in vitro. Objectives: We hypothesised that spectral analysis heart rate variability (HRV) might detect differences between their anticholinergic activities following a single peroral administration. Methods: this double-blind, cross-over study, amitriptyline (75 mg), (20 (4 mg) placebo were randomly given at 1-week intervals to eight healthy male volunteers. Drug catecholamine concentrations plasma determined repeatedly. The drug effect was assessed periodic recordings electrocardiogram (ECG) blood pressure, measurements salivary secretion. ECG subjected HRV, which high frequency (HF) power R–R interval (RRI) supposed reflect cardiac parasympathetic tone. Results: Reboxetine increased pressure reduced HF RRI 3,4-dihydroxyphenylglycol (DHPG) concentrations. Amitriptyline diminished secretion had prominent sedative action. Measurements after did not differ significantly from placebo. Conclusions: Reboxetine, its vitro, distinct on RRI, consistent vivo. measurable glands, but, surprisingly, heart. suggest could alter sympathovagal balance and, therefore, counteract effect.