Visceral leishmaniasis in patients with lymphoma: Case reports and review of the literature.

摘要: Introduction Non-HIV-related visceral leishmaniasis (VL) is becoming increasingly prevalent in nontropical countries because of the increasing number patients with chronic diseases and development immune-modulating drugs. Patient concerns Case 1 a 60-year-old male patient Senegalese origin presented weight loss, lymphadenopathy, anemia, elevated lactate dehydrogenases. 2 46-year-old Algerian origin, negative HIV serology cutaneous lesions. Diagnosis 1: The diagnosis stage IV lymphocytic lymphoma (LL) was confirmed by an inguinal nodal biopsy 2013. 2: T-cell made 2003. Interventions received 5 cycles bendamustine rituximab followed complete remission. initially treated >10 different treatments 8 chemotherapy regimens due to disease progression. Outcomes In 2017, after follow-up 4 years, fever, splenomegaly, pancytopenia setting hemophagocytic syndrome. initial relapse ibrutinib. His status worsened, Leishmania DNA detected polymerase chain reaction (PCR) on blood bone marrow aspirates. Ibrutinib stopped. Amphotericin B treatment induced clinical remission clearance from blood.Patient 14 hepatosplenomegaly, syndrome, increase tumor skin A taken face patient. careful reexamination revealed presence bodies. He 40 mg/kg liposomal amphotericin leading regression symptoms negativation PCR. Conclusions This case study shows that VL may be diagnostic challenge lymphoma. Reactivation or primary infection should considered differential diagnosis. purpose this remind clinicians think systemic could misdiagnosed as progression underlying