Suppression of immune function and susceptibility to infections in humans: association of immune function with clinical disease.

摘要: A number of regulatory agencies in western Europe, Japan and the United States now include guidelines for evaluating potential immunotoxicity chemicals, including drugs, as part routine toxicity testing. Most testing recommend observational or functional assays that, based on studies laboratory animals, are able to detect changes immune function that associated with increased susceptibility infectious neoplastic cell challenge. To appreciate how well endpoints likely predict an risk infection humans, it is important establish correlations between alterations human disease. This review will address clinical evidence disease humans mild moderate levels immunosuppression using examples from literature, discuss specific system defects rates infection, examine factors impact interpreta...