摘要: Human innate immune cells exposed to certain infections or stimuli develop enhanced responses upon re-infection with a different second stimulus, process termed trained immunity. Recent studies have revealed that hematopoietic stem (HSCs) are integral as they able "remember" transcriptional and transmit this state their progeny educate them how respond future infections. The macrophages arise from HSCs epigenetically reprogrammed result robustly express genes, enhancing capability resolve infection. Accumulation of H3K4me3 epigenetic marks on multiple gene promoters underlie robust during responses. However, the mechanism underpinning these accumulate at discrete loci has been poorly understood. In review, we discuss previously unexplored contributions nuclear architecture long non-coding RNAs promoter priming in Altering activity lncRNAs presents promising therapeutic approach achieve immunomodulation inflammatory disease states.
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