A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy
作者： Samira Imran , Melanie R. Neeland , Rebecca Shepherd , Nicole Messina , Kirsten P. Perrett
DOI: 10.1016/J.ISCI.2020.101171
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摘要: The prevalence of IgE-mediated food allergy is increasing at a rapid pace in many countries. association high rates with Westernized lifestyles suggests the role gene-environment interactions, potentially underpinned by epigenetic variation, mediating this process. Recent studies have implicated innate immune system dysfunction development and persistence allergy. These responses are characterized increased circulating frequency cells heightened inflammatory to bacterial stimulation allergic patients. signatures mirror those described trained immunity, whereby retain "memory" earlier microbial encounters, thus influencing subsequent responses. Here, we propose that robust multi-omics approach integrates immunological, transcriptomic, epigenomic datasets, combined well-phenotyped longitudinal cohorts, can inform potential immunity
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