Seroprevalence of immunoglobulin M (IgM) and IgG antibodies to polysaccharides of Streptococcus pneumoniae in different age groups of Ecuadorian and German children.

摘要: Abstract The age-specific prevalence of serum immunoglobulin M (IgM) antibody to capsular polysaccharides Streptococcus pneumoniae, as detected by enzyme-linked immunosorbent assay, was studied in 1,301 Ecuadorian children enrolled a national nutrition and health survey. This 6% infants < 6 months old increased 28% 11 old, 49% those 12 17 58% 18 23 old. About 80% the 5-year-old had this antibody. When tested separately against six different polysaccharides, IgM reacted with decreasing frequency serotype 3, 8, 19, 6, 23, 1 polysaccharides. We did not observe broadening response increasing age sense that more serotypes were recognized. A similar age-related found for species-specific C-polysaccharide S. pneumoniae IgG pneumoniae. smaller German collection showed comparable pneumococcus-specific antibodies. The highest incidence respiratory diseases observed 1- 2-year-old children. It thus seems acquisition reflects developmental maturation an immune than actual exposure pneumococcal serotypes.