Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
作者： Mustafa Işın , Ege Uysaler , Emre Özgür , Hikmet KöseoÄŸlu , Öner Åžanlı
关键词:
摘要: Exosomes are membranous vesicles containing various biomolecules including lncRNAs which involved in cellular communication and secreted from many cells cancer cells. In our study, investigated the exosomal GAS5 lincRNA-p21 lncRNA levels urine samples 30 patients with prostate (PCa) 49 benign prostatic hyperplasia. Quantification of molecules was performed by real-time PCR. We observed a significant difference between PCa BPH whereas did not reveal difference. Our data suggest that discriminative potential may help to improve diagnostic prediction malignant state for PCa.
frontiersin.org
elsevier.com
baskent.edu.tr
researchgate.net 
core.ac.uk 
sci-hub.se 参考文章(44)
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Kiren Yacqub-Usman, Mark R. Pickard, Gwyn T. Williams, Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells. The Prostate. ,vol. 75, pp. 693- 705 ,(2015) , 10.1002/PROS.22952
Douglas D. Taylor, Sibel Akyol, Cicek Gercel-Taylor, Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling The Journal of Immunology. ,vol. 176, pp. 1534- 1542 ,(2006) , 10.4049/JIMMUNOL.176.3.1534
Fulya Yaman Agaoglu, Müge Kovancilar, Yavuz Dizdar, Emin Darendeliler, Stefan Holdenrieder, Nejat Dalay, Ugur Gezer, Investigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer Tumor Biology. ,vol. 32, pp. 583- 588 ,(2011) , 10.1007/S13277-011-0154-9
Lucas Nogueira, Renato Corradi, James A. Eastham, Other biomarkers for detecting prostate cancer. BJUI. ,vol. 105, pp. 166- 169 ,(2010) , 10.1111/J.1464-410X.2009.09088.X
Richard J. Simpson, Søren S. Jensen, Justin W. E. Lim, Proteomic profiling of exosomes: Current perspectives Proteomics. ,vol. 8, pp. 4083- 4099 ,(2008) , 10.1002/PMIC.200800109
Giuseppe Lippi, Martina Montagnana, Gian Cesare Guidi, Mario Plebani, Prostate-specific antigen-based screening for prostate cancer in the third millennium: useful or hype? Annals of Medicine. ,vol. 41, pp. 480- 489 ,(2009) , 10.1080/07853890903156468
Hiroyuki Nakanishi, Jack Groskopf, Herbert A Fritsche, Viju Bhadkamkar, Amy Blase, S Vikas Kumar, John W Davis, Patricia Troncoso, Harry Rittenhouse, R Joseph Babaian, None, PCA3 molecular urine assay correlates with prostate cancer tumor volume: implication in selecting candidates for active surveillance. The Journal of Urology. ,vol. 179, pp. 1804- 1810 ,(2008) , 10.1016/J.JURO.2008.01.013
Claudia Bang, Thomas Thum, Exosomes: New players in cell–cell communication The International Journal of Biochemistry & Cell Biology. ,vol. 44, pp. 2060- 2064 ,(2012) , 10.1016/J.BIOCEL.2012.08.007
Xiaoyi Huang, Tiezheng Yuan, Meihua Liang, Meijun Du, Shu Xia, Rachel Dittmar, Dian Wang, William See, Brian A. Costello, Fernando Quevedo, Winston Tan, Debashis Nandy, Graham H. Bevan, Sherri Longenbach, Zhifu Sun, Yan Lu, Tao Wang, Stephen N. Thibodeau, Lisa Boardman, Manish Kohli, Liang Wang, Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer European Urology. ,vol. 67, pp. 33- 41 ,(2015) , 10.1016/J.EURURO.2014.07.035