Fgf-3, an oncogene in murine breast cancer

摘要: Cancer originates from cells that have acquired a succession of genetic changes progressively enable them to proliferate outside the constraints normal growth control. The earliest are considered impinge on very few or even single cells, providing with advantage facilitates their clonal expansion, and leads production significant population can act as target for secondary mutations. Thus alterations been envisaged may result in inappropriate induction potent cell signaling molecules function factors and/or promote neovascularization, loss functions normally inhibit proliferation, enzymes affect tissue remodeling. basis this conceptual framework, identification candidate gene products involved neoplastic transformation, has arisen large part study tumors animal systems.