Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes

摘要: During development cells of the oligodendrocyte lineage undergo significant changes in morphology when they differentiate from migratory progenitors, which are mostly bipolar, into post-migratory pre-myelinating oligodendrocytes, extend complex and expanded process networks, then finally mature generate myelin sheaths required for efficient signal propagation within nervous system. This extensive morphological remodeling occurs context a extracellular environment requires rearrangement cell's cytoskeleton. The molecular mechanisms underlying this intricate integration signals, however, remain poorly understood. A key regulator matrix to cytoskeleton signaling is non-receptor tyrosine kinase FAK (focal adhesion kinase). Here, we report that can regulate differentiating oligodendrocytes unique opposing fashion dependent on nature mediated largely by FAK's catalytic activity. More specifically, was found restrict network expansion presence fibronectin but promote maturation laminin-2. In addition, restraining role predominated postnatal day 3-derived cells, while its promoting prevailed 5-derived cells. Taken together, our findings reveal regulating oligodendrocytes.