Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells.
作者： Xiaoying Zhang , Wei Chen , Ruth Guillermo , Gudiseva Chandrasekher , Radhey S Kaushik
关键词:
摘要: Background α-Santalol, an active component of sandalwood oil, has shown chemopreventive effects on skin cancer in different murine models. However, α-santalol cell cycle have not been studied. Thus, the objective this study was to investigate progression both p53 mutated human epidermoid carcinoma A431 cells and wild-type melanoma UACC-62 elucidate mechanism(s) action.
biomedcentral.com
springer.com
core.ac.uk
paperity.org参考文章(35)
Janine G. Einspahr, G. Timothy Bowden, David S. Alberts, Skin cancer chemoprevention: strategies to save our skin. Recent results in cancer research. ,vol. 163, pp. 151- 164 ,(2003) , 10.1007/978-3-642-55647-0_14
H. P. Koeffler, A. M. Chumakov, Dan Lin Chen, D. J. Park, C. W. Miller, H. Nakamura, J. W. Said, Transactivational and DNA Binding Abilities of Endogenous p53 in p53 Mutant Cell Lines Oncogene. ,vol. 9, pp. 1899- 1906 ,(1994)
Andreas Gescher, Ugo Pastorino, Simon M. Plummer, Margaret M. Manson, Suppression of tumour development by substances derived from the diet—mechanisms and clinical implications web science. ,vol. 45, pp. 1- 12 ,(1998) , 10.1046/J.1365-2125.1998.00640.X
Bhanu L. Arasada, Chandradhar Dwivedi, Ajay Bommareddy, Kathryn Bremmon, Xiaoying Zhang, Effects of α-Santalol on Proapoptotic Caspases and p53 Expression in UVB Irradiated Mouse Skin Anticancer Research. ,vol. 28, pp. 129- 132 ,(2008)
Chandradhar Dwivedi, Ajay Bommareddy, Justin Hora, Bruce Cornish, Chemoprevention by α-Santalol on UVB Radiation-induced Skin Tumor Development in Mice Anticancer Research. ,vol. 27, pp. 2185- 2188 ,(2007)
Kenneth G. Linden, Philip M. Carpenter, Christine E. McLaren, Ronald J. Barr, Pamela Rite, Joannie D. Sun, Kou-Tung Li, Jaye L. Viner, Frank L. Meyskens, Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea. Recent results in cancer research. ,vol. 163, pp. 165- 171 ,(2003) , 10.1007/978-3-642-55647-0_15
R. J. Michalides, Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer. Journal of Clinical Pathology. ,vol. 52, pp. 555- 568 ,(1999) , 10.1136/JCP.52.8.555
Xiaoying Zhang, Ajay Bommareddy, Wei Chen, Sherief Khalifa, Radhey S. Kaushik, Hesham Fahmy, Chandradhar Dwivedi, Sarcophine-diol, a Chemopreventive Agent of Skin Cancer, Inhibits Cell Growth and Induces Apoptosis through Extrinsic Pathway in Human Epidermoid Carcinoma A431 Cells. Translational Oncology. ,vol. 2, pp. 21- 30 ,(2009) , 10.1593/TLO.08190
Vladimir JN Bykov, Natalia Issaeva, Galina Selivanova, Klas G Wiman, Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis. ,vol. 23, pp. 2011- 2018 ,(2002) , 10.1093/CARCIN/23.12.2011
Young-Joon Surh, Cancer chemoprevention with dietary phytochemicals Nature Reviews Cancer. ,vol. 3, pp. 768- 780 ,(2003) , 10.1038/NRC1189