Mycophenolate mofetil-induced neutropenia in liver transplantation.

摘要: Background. Mycophenolate mofetil (MMF) is a potent, safe immunosuppressive agent for rescue therapy of acute and chronic rejection in orthotopic liver transplant recipients. It helps to reduce the serious toxic side effects calcineurin inhibitors (CNIs). The MMF, such as bone marrow toxicity, have been reported. Herein we report four patients who underwent transplantation developed neutropenia while receiving MMF. Methods. Between April 2002 October 2003, performed 24 transplants 25 patients. Eighteen were given MMF following reasons: renal failure nine (50%); treatment three (16.6%); primary prophylaxis five (27.7%); CNI withdrawal one (5.5%). Results. Of 18 treated with there 11 men (61.1%) seven women (38.8%), an overall mean age 55.5 years. This was ceased due (22%). Discontinuation followed by rapid spontaneous rise neutrophils two Granulocyte colony stimulating factor (GCSF) administered patient another biopsy persistent anemia, leukopenia, thrombocytopenia. time from starting development 4 months. Only third showed elevated levels Conclusions. potent transplantation. However, because hematologic toxicity has reported, recommend caution administration careful monitoring blood levels.